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While this is not a common side effect, changes in urine can happen for several reasons

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Recently, NTZ has been repurposed to treat hyperlipidemia, hepatic steatosis (Li et al., 2022), as well as atherosclerosis (Ma et al., 2023)

Moreover, oxidative stress upregulates adhesion molecules like intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on orbital fibroblasts and endothelial cells, facilitating immune cell recruitment and adhesion to inflamed orbital tissue (88, 89)